The match, scheduled for Tuesday 15th October, will kick off at 7.45pm. No ticket information is currently available. Once available it will be on Reading MAD.
England U21 have played at the Madejski twice before, and have come away with large victories on both occasions. The first game, in Novmeber 1999, against Luxembourg was played in front of a 17,000 strong crowd. England won by five goals to nil.
Then last summer David Platt made his debut as U21 manager in Reading. His side, which included World Cup star Darius Vassell, won 4-0. England coach Sven-Goran Erikkson was in attendance.
Players such as Peter Crouch, Jermaine Pennant, Jermaine Jenas, Peter Crouch, Michael Carrick, Gareth Barry and Chris Kirkland are likely to be in Platt's squad for the Macedonia game.
A thefa.com spokesman said: "England will be highly motivated to erase the disappointment of Switzerland and qualify for the finals in two years' time.
"It will be no easy task though. The campaign will kick off away to Slovakia on Friday 11th October. Our group group features powerhouses Portugal, who have beaten England in their last two encounters as well as and Turkey, who will be looking to follow in the footsteps of their senior counterparts (who finished third at the World Cup)."