Tottenham midfielder Teemu Tainio has a calf problem and striker Mido is also struggling with a calf complaint.
Ledley King (feet), Benoit Assou-Ekotto (knee), Danny Murphy (Achilles) and Anthony Gardner (leg) are sidelined, and Hossam Ghaly has the flu.
Reading will be without Graeme Murty after the right-back reported back from Scotland duty with a calf injury.
Record signing Greg Halford could make his first start, although the other option is playing Ulises de la Cruz.
Tottenham (from): Robinson, Cerny, Alnwick, Chimbonda, Stalteri, Lee, Dawson, Rocha, Huddlestone, Zokora, Jenas, Lennon, Malbranque, Taarabt, Keane, Berbatov, Mido, Defoe.
Reading (from): Hahnemann, Halford, Ingimarsson, Bikey, Duberry, Shorey, Little, Sidwell, Harper, Hunt, Lita, Kitson, Doyle, Long, Federici, De la Cruz, Gunnarsson, Oster.