Ibrahima Sonko is fit but Dave Kitson, Sam Sodje, Peter Mate, Aaron Brown and Simon Cox are out and Seol Ki-Hyeon's fitness will be assessed.
Ashley Cole is the main doubt for Chelsea after suffering a leg injury in England's 2-0 defeat by Croatia.
German midfielder Michael Ballack is still suspended.
Reading (from): Hahnemann, Murty, de la Cruz, Sonko, Ingimarsson, Shorey, Seol, Little, Sidwell, Harper, Convey, Lita, Doyle, Long, Stack, Halls, Bikey, Gunnarsson, Oster, Hunt.
Chelsea (from): Cech, Cudicini, Ferreira, Bridge, Cole, Geremi, Terry, Carvalho, Lampard, Diarra, Makelele, Robben, Wright-Phillips, Boulahrouz, Drogba, Shevchenko, Kalou, Essien.