Coppell made four changes at the weekend in a desperate bid to find some form but saw his side lose 1-0 at home to Ipswich and fall 10 points adrift of Championship leaders Wolves.
Top scorer Kevin Doyle was the biggest name to be left out as Coppell gave Dave Kitson a second debut in attack after he signed on loan from Stoke, but the Republic of Ireland international may return at the Keepmoat.
Goalkeeper Marcus Hahnemann also returned in place of Adam Federici for his first appearance since suffering a torn calf muscle in early December, with Coppell claiming his extra experience will benefit the Royals.
Winger Jimmy Kebe has recovered from a slight knee injury and will vie with Glen Little for a start on the right of midfield.
Ivar Ingimarsson is out for the rest of the season with a knee injury while club captain Graeme Murty is sidelined with another calf injury.
Doncaster are set to give Brian Stock a late fitness test.
The midfielder managed to play the first half of Saturday's 2-0 defeat to Birmingham having recieved an injection to help clear up a back injury prior to the game but was taken off at half-time after suffering a recurrence of the problem.
Fellow midfielder Richie Wellens was also substituted at half-time against the Blues after picking up a groin injury but is expected to be fit in time to feature against the Royals.
Right-back James O'Connor has had an injection on his ankle injury and started running on Monday but is rated as a major doubt for the clash at the Keepmoat Stadium.
Meanwhile, striker Steve Brooker (ankle) and midfielder Stuart Elliot (knee) remain on the sidelines.
Sporting Life